Role of lipid rafts in the processing of the pathogenic prion and Alzheimer's amyloid-beta proteins
Write to authors to ask them to make this article freely available at NoL Archive
Semin Cell Dev Biol. 2007 Jul 24 ePpub ahead of print
Taylor DR, Hooper NM.
Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
The conformational conversion of the cellular form of the prion protein (PrP(C)) into the infectious form (PrP(Sc)) and the proteolytic processing of the amyloid-beta (Abeta) peptide are central pathogenetic events in the prion diseases and Alzheimer's disease, respectively. Cholesterol- and sphingolipid-rich lipid rafts have emerged as important sites for the conversion of PrP(C) into PrP(Sc), and for the proteolytic production, degradation and aggregation of Abeta. Here, we discuss these findings and their implications for our understanding of these disease processes. In addition, the potential for rafts as sites for therapeutic intervention in prion diseases and Alzheimer's disease is considered.
PubMed ID and Record
Semin Cell Dev Biol. 2007 Jul 24 ePpub ahead of print
Taylor DR, Hooper NM.
Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
The conformational conversion of the cellular form of the prion protein (PrP(C)) into the infectious form (PrP(Sc)) and the proteolytic processing of the amyloid-beta (Abeta) peptide are central pathogenetic events in the prion diseases and Alzheimer's disease, respectively. Cholesterol- and sphingolipid-rich lipid rafts have emerged as important sites for the conversion of PrP(C) into PrP(Sc), and for the proteolytic production, degradation and aggregation of Abeta. Here, we discuss these findings and their implications for our understanding of these disease processes. In addition, the potential for rafts as sites for therapeutic intervention in prion diseases and Alzheimer's disease is considered.
PubMed ID and Record
0 Comments:
Post a Comment
<< Home